An overlooked neurotoxic species in Alzheimer's disease

被引：13

作者：

Benilova, Iryna ^{[1
,2
]}

De Strooper, Bart ^{[1
,2
]}

机构：

[1] Univ Leuven, Ctr Human Genet, Louvain, Belgium

[2] Flanders Inst Biotechnol, Dept Mol & Dev Genet, Louvain, Belgium

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 08期

关键词：

AMYLOID-BETA-PROTEIN; GAMMA-SECRETASE; PRESENILIN MUTATIONS; HYPOTHESIS; A-BETA-40;

D O I：

10.1038/nn.2871

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

A study now finds early memory impairment in a mouse model of amyloid beta 43 (A beta 43)-overproducing familial Alzheimer's disease and suggests that this overlooked amyloidogenic A beta species contributes to pathology.

引用

页码：949 / 950

页数：2

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