25 years after the nucleosome model: chromatin modifications

被引：301

作者：

Wu, JS ^{[1
]}

Grunstein, M

机构：

[1] Univ Calif Los Angeles, Dept Biol Chem, Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(00)01718-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleosomes play a dynamic role in transcription. The key to this role is the structure of the flexible and charged histone tails that extend from the hydrophobic nucleosome core, These tails are modified by acetylation and deacetylation, phosphorylation, methylation, ubiquitination and ATP-dependent chromatin remodeling, and they regulate functions as diverse as transcription, DNA-dependent chromatin assembly, DNA repair, mitosis and silencing by heterochromatin.

引用

页码：619 / 623

页数：5

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