It's a mod mod tRNA world

被引：11

作者：

Maraia, Richard J. ^{[1
]}

Blewett, Nathan H. ^{[1
]}

Bayfield, Mark A. ^{[1
]}

机构：

[1] NICHHD, NIH, Intramural Res Program, Bethesda, MD 20892 USA

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 03期

关键词：

D O I：

10.1038/nchembio0308-162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Postsynthetic modifications are widespread in genetic regulation. Trm9-mediated modification of the anticodon wobble base of specific tRNAs modulates expression of DNA damage response mRNAs in which cognate codons are unusually overrepresented. Thus, modification-dependent tRNA decoding activity is keyed to codon use in a genetic program.

引用

页码：162 / 164

页数：3

共 11 条

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