Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering

被引：56

作者：

Kim, HW ^{[1
]}

Noh, YJ ^{[1
]}

Koh, YH ^{[1
]}

Kim, HE ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Mat Sci & Engn, Seoul 151742, South Korea

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2003年 / 14卷 / 10期

关键词：

D O I：

10.1023/A:1025638811361

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al2O3) were successfully fabricated without applying pressure at 1400degreesC for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than similar to2-4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days. (C) 2003 Kluwer Academic Publishers.

引用

页码：899 / 904

页数：6

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