A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells

被引：178

作者：

Ibarra, Ingrid ^{[1
,2
]}

Erlich, Yaniv ^{[1
]}

Muthuswamy, Senthil K. ^{[1
]}

Sachidanandam, Ravi ^{[1
]}

Hannon, Gregory J. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA

来源：

GENES & DEVELOPMENT | 2007年 / 21卷 / 24期

关键词：

RNAi; microRNA; stem cell; ALDEHYDE DEHYDROGENASE-ACTIVITY; HEMATOPOIETIC STEM-CELLS; ACUTE MYELOID-LEUKEMIA; IDENTIFICATION; LINE; RNA; EXPRESSION; MATURATION; RESISTANCE; DROSOPHILA;

D O I：

10.1101/gad.1616307

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNA (miRNA) expression profiles are often characteristic of specific cell types. The mouse mammary epithelial cell line, Comma-D beta, contains a population of self-renewing progenitor cells that can reconstitute the mammary gland. We purified this population and determined its miRNA signature. Several microRNAs, including miR-205 and miR-22, are highly expressed in mammary progenitor cells, while others, including let-7 and miR-93, are depleted. Let-7 sensors can be used to prospectively enrich self-renewing populations, and enforced let-7 expression induces loss of self-renewing cells from mixed cultures.

引用

页码：3238 / 3243

页数：6

共 32 条

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