Hyperventilation alters colonic motor and sensory function: Effects and mechanisms in humans

被引:22
作者
Bharucha, AE
Camilleri, M
Ford, MJ
OConnor, MK
Hanson, RB
Thomforde, GM
机构
[1] MAYO CLIN & MAYO FDN, GASTROENTEROL RES UNIT, ROCHESTER, MN 55905 USA
[2] MAYO CLIN & MAYO FDN, DIV NUCL MED, ROCHESTER, MN 55905 USA
关键词
D O I
10.1053/gast.1996.v111.pm8690201
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Hyperventilation-induced hypocapnia affects hemodynamic function and enhances colonic motility. The aims of this study were to determine the effects of hypocapnic hyperventilation on colonic motility and sensation in health and to explore the putative neurohumoral mechanisms. Methods: In experiment 1, colonic tone, sensation, plasma levels of cortisol, beta-endorphin, selected gut neuropeptides, norepinephrine, epinephrine, and splanchnic blood volume were measured during two sequences of hypocapnic hyperventilation. In experiment 2, colonic tone and sensation were assessed during eucapnic hyperventilation and abdominal compression. Results: Hypocapnic hyperventilation, but not eucapnic hyperventilation or abdominal compression, significantly increased colonic tone and sensitivity to balloon distention (P = 0.017) without altering humoral mediators or splanchnic blood volume. Plasma norepinephrine level increased (P = 0.017) and splanchnic blood volume decreased (P = 0.028) during 5 minutes after hyperventilation, consistent with homeostatic responses. Conclusions: Increased colonic tone and sensation during hypocapnic hyperventilation are not caused by colonic compression. These effects of hyperventilation are not mediated humorally but may result from direct metabolic effects of hypocapnia on colonic muscle or from changes in central autonomic control of colonic smooth muscle.
引用
收藏
页码:368 / 377
页数:10
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