Regulation of myosin heavy chain expression in adult rat hindlimb muscles during short-term paralysis: Comparison of denervation and tetrodotoxin-induced neural inactivation

被引：46

作者：

Michel, RN ^{[1
]}

Parry, DJ ^{[1
]}

Dunn, SE ^{[1
]}

机构：

[1] UNIV OTTAWA,FAC MED,DEPT PHYSIOL,OTTAWA,ON K1H 8M5,CANADA

来源：

FEBS LETTERS | 1996年 / 391卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会; 英国医学研究理事会;

关键词：

myosin; immunohistochemistry; activity; trophic mechanism; embryonic MHC; alpha-cardiac MHC;

D O I：

10.1016/0014-5793(96)00618-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extent to which myosin profiles within adult fast and slow muscles are altered by short-term paralysis remains equivocal. We used an array of specific antibodies to identify adult and developmental MHC isoforms within EDL and soleus muscle fibers, and show a marked multiple expression of MHCs with a general shift towards slower and more energy efficient MHC profiles after 2 weeks of denervation or TTX nerve conduction block, Paralysis also induced marked expression of an embryonic MHC within most EDL cell types, and a subtle, paralysis-sensitive, expression of alpha-cardiac MHC within specific EDL and soleus extrafusal fibers, Comparison of treatment groups also permitted assessment of the relative influence of neural activity versus trophic factors on these isoforms, and confirmed activity as a major, but not sole, regulator of MHC expression.

引用

页码：39 / 44

页数：6