Protein kinase C isoenzyme:: selective expression pattern of protein kinase C-θ during mouse development

被引：16

作者：

Wilda, M

Ghaffari-Tabrizi, N

Reisert, I

Utermann, G

Baier, G

Hameister, H ^{[1
]}

机构：

[1] Univ Ulm, Abt Humangenet, D-89069 Ulm, Germany

[2] Univ Innsbruck, Inst Med Biol & Humangenet, A-6020 Innsbruck, Austria

[3] Univ Ulm, Anat & Zellbiol Abt, D-89069 Ulm, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 103卷 / 1-2期

关键词：

protein kinase C-theta; RNA in situ hybridization; hematopoiesis; lymphopoiesis; yolk sac; liver; thymus; spleen; afferent neuronal conduction; dorsal root ganglia; trigeminal and facial ganglia; alar plate; gracile and cuneate fasciculi; medial lemniscus; thalamus; olfactory system; mitral cell layer; of olfactory bulb; interneuron layer of praepiriform cortex amygdaloid area; medial habenulae; cerebellum; choroid plexus;

D O I：

10.1016/S0925-4773(01)00357-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protein kinase C (PKC)-theta, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKC theta is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

共 13 条

[1] Protein kinase Cθ:: a new essential superstar on the T-cell stage [J].