Cranberry extract inhibits low density lipoprotein oxidation

被引：4

作者：

Wilson, T ^{[1
]}

Porcari, JP

Harbin, D

机构：

[1] Univ Wisconsin, La Crosse Exercise & Hlth Program, La Crosse, WI 54601 USA

[2] Gundersen Lutheran Med Ctr, La Crosse, WI 54601 USA

来源：

LIFE SCIENCES | 1998年 / 62卷 / 24期

关键词：

cranberry; Vaccinium macrocarpon antioxidant; flavonoid;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cranberry juice consumption is often used for the treatment of urinary tract infections, but the effect of cranberry juice on heart disease has not been investigated. We evaluated how a cranberry extract containing 1,548 mg gallic acid equivalents/liter (initial pH=2.50) affected low density lipoprotein (LDL) oxidation induced by 10 micromolar cupric sulfate. When LDL oxidation took place in the presence of diluted cranberry extracts, the formation of thiobarbituric acid reactive substances (TBARS) and LDL electrophoretic mobility were reduced. LDL electrophoretic migration was also reduced when the cranberry extract had a pH of 7.00 prior to dilution. This study suggests that cranberry extracts have the ability to inhibit the oxidative modification of LDL particles. (C) 1998 Elsevier Science Inc.

引用

页码：PL381 / PL386

页数：6

共 18 条

[1] Phenolic content of various beverages determines the extent of inhibition of human serum and low-density lipoprotein oxidation in vitro: Identification and mechanism of action of some cinnamic acid derivatives from red wine [J].

AbuAmsha, R ;

Croft, KD ;

Puddey, IB ;

Proudfoot, JM ;

Beilin, LJ .

CLINICAL SCIENCE, 1996, 91 (04) :449-458

[2] REDUCTION OF BACTERIURIA AND PYURIA AFTER INGESTION OF CRANBERRY JUICE [J].

AVORN, J ;

MONANE, M ;

GURWITZ, JH ;

GLYNN, RJ ;

CHOODNOVSKIY, I ;

LIPSITZ, LA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (10) :751-754

[3] In vitro anticancer activity of fruit extracts from Vaccinium species [J].

Bomser, J ;

Madhavi, DL ;

Singletary, K ;

Smith, MAL .

PLANTA MEDICA, 1996, 62 (03) :212-216

[4] Novel lipid-lowering properties of Vaccinium myrtillus L leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: A comparison with ciprofibrate [J].

Cignarella, A ;

Nastasi, M ;

Cavalli, E ;

Puglisi, L .

THROMBOSIS RESEARCH, 1996, 84 (05) :311-322

[5]

COLANTUONI A, 1991, ARZNEIMITTELFORSCH, V41-2, P905

[6]

DEMROW HS, 1995, CIRCULATION, V91, P1181

[7]

FITZPATRICK DF, 1993, AM J PHYSIOL, V265, pH774

[8]

Fraisse Didier, 1996, Annales Pharmaceutiques Francaises, V54, P280

[9] CONSUMPTION OF RED WINE WITH MEALS REDUCES THE SUSCEPTIBILITY OF HUMAN PLASMA AND LOW-DENSITY-LIPOPROTEIN TO LIPID-PEROXIDATION [J].

FUHRMAN, B ;

LAVY, A ;

AVIRAM, M .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (03) :549-554

[10] RRR-alpha-tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus [J].

Fuller, CJ ;

Chandalia, M ;

Garg, A ;

Grundy, SM ;

Jialal, I .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1996, 63 (05) :753-759

← 1 2 →