Total structures of colistin minor components

被引：24

作者：

Ikai, Y

Oka, H

Hayakawa, J

Kawamura, N

Mayumi, T

Suzuki, M

Harada, K

机构：

[1] Aichi Prefectural Inst Publ Hlth, Kita Ku, Nagoya, Aichi 4628576, Japan

[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 05期

关键词：

D O I：

10.7164/antibiotics.51.492

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structural characterization of the colistin (CL) components were carried out using Frit-fast atom bombardment liquid chromatography/mass spectrometry (Frit-FAB LC/MS), tandem mass spectrometry (MS/MS) and the amino acid analysis proposed by MARFEY, and the total structures of 4 minor components including the absolute configuration of the constituent amino acids were proposed. The structures of the minor components were the same as those of the main component colistin A or B except that L-leucine is replaced by L-valine or L-isoleucine.

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页码：492 / 498

页数：7

相关论文

共 14 条

[1] CONTRIBUTIONS OF MASS-SPECTROMETRY TO PEPTIDE AND PROTEIN-STRUCTURE [J].

BIEMANN, K .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1988, 16 (1-12) :99-111

[2] ISOLATION AND CHARACTERIZATION OF 3 NEW POLYMYXINS IN POLYMYXIN-B AND POLYMYXIN-E BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

ELVERDAM, I ;

LARSEN, P ;

LUND, E .

JOURNAL OF CHROMATOGRAPHY, 1981, 218 (1-3) :653-661

[3] CHEMICAL STRUCTURE OF CIRCULIN A [J].

FUJIKAWA, K ;

SUKETA, Y ;

HAYASHI, K ;

SUZUKI, T .

EXPERIENTIA, 1965, 21 (06) :307-&

[4] CHEMICAL STRUCTURE OF CIRCULIN B [J].

HAYASHI, K ;

SUKETA, Y ;

SUZUKI, T .

EXPERIENTIA, 1968, 24 (07) :656-&

[5] Isolation of colistin A and B using high-speed countercurrent chromatography [J].

Ikai, Y ;

Oka, H ;

Hayakawa, J ;

Kawamura, N ;

Harada, K ;

Suzuki, M ;

Nakazawa, H ;

Ito, Y .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 1998, 21 (1-2) :143-155

[6] TOTAL STRUCTURES AND ANTIMICROBIAL ACTIVITY OF BACITRACIN MINOR COMPONENTS [J].

IKAI, Y ;

OKA, H ;

HAYAKAWA, J ;

MATSUMOTO, M ;

SAITO, M ;

HARADA, K ;

MAYUMI, T ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1995, 48 (03) :233-242

[7] STRUCTURAL CHARACTERIZATION OF BACITRACIN COMPONENTS BY FRIT-FAST ATOM BOMBARDMENT (FAB) LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY (LC/MS) [J].

IKAI, Y ;

OKA, H ;

HAYAKAWA, J ;

HARADA, K ;

SUZUKI, M .

JOURNAL OF ANTIBIOTICS, 1992, 45 (08) :1325-1334

[8]

IKAI Y, 1991, MASS SPECTROSC, V39, P199

[9] ANALYTICAL AND PREPARATIVE METHODS FOR POLYMYXIN ANTIBIOTICS USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH A POROUS STYRENE-DIVINYLBENZENE CO-POLYMER PACKING [J].

KIMURA, Y ;

KITAMURA, H ;

ARAKI, T ;

NOGUCHI, K ;

BABA, M ;

HORI, M .

JOURNAL OF CHROMATOGRAPHY, 1981, 206 (03) :563-572

[10]

Koyama Y., 1950, J.Antibiot, V3, P457