Total structures of colistin minor components

被引：24

作者：

Ikai, Y

Oka, H

Hayakawa, J

Kawamura, N

Mayumi, T

Suzuki, M

Harada, K

机构：

[1] Aichi Prefectural Inst Publ Hlth, Kita Ku, Nagoya, Aichi 4628576, Japan

[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 05期

关键词：

D O I：

10.7164/antibiotics.51.492

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structural characterization of the colistin (CL) components were carried out using Frit-fast atom bombardment liquid chromatography/mass spectrometry (Frit-FAB LC/MS), tandem mass spectrometry (MS/MS) and the amino acid analysis proposed by MARFEY, and the total structures of 4 minor components including the absolute configuration of the constituent amino acids were proposed. The structures of the minor components were the same as those of the main component colistin A or B except that L-leucine is replaced by L-valine or L-isoleucine.

引用

页码：492 / 498

页数：7

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