Finding a protein's Achilles heel

被引：27

作者：

Matouschek, A

Bustamante, C

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 09期

关键词：

D O I：

10.1038/nsb0903-674

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent ensemble and single molecule manipulation studies highlight the mechanical nature of protein unfolding in vivo and, thus, the greater need to understand the response of proteins to mechanical force.

引用

页码：674 / 676

页数：3

共 24 条

[1] Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation [J].

Best, RB ;

Li, B ;

Steward, A ;

Daggett, V ;

Clarke, J .

BIOPHYSICAL JOURNAL, 2001, 81 (04) :2344-2356

[2] BEAD MOVEMENT BY SINGLE KINESIN MOLECULES STUDIED WITH OPTICAL TWEEZERS [J].

BLOCK, SM ;

GOLDSTEIN, LSB ;

SCHNAPP, BJ .

NATURE, 1990, 348 (6299) :348-352

[3] Pulling geometry defines the mechanical resistance of a β-sheet protein [J].

Brockwell, DJ ;

Paci, E ;

Zinober, RC ;

Beddard, GS ;

Olmsted, PD ;

Smith, DA ;

Perham, RN ;

Radford, SE .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :731-737

[4] The mechanical stability of ubiquitin is linkage dependent [J].

Carrion-Vazquez, M ;

Li, HB ;

Lu, H ;

Marszalek, PE ;

Oberhauser, AF ;

Fernandez, JM .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :738-743

[5] Mechanical and chemical unfolding of a single protein: A comparison [J].

Carrion-Vazquez, M ;

Oberhauser, AF ;

Fowler, SB ;

Marszalek, PE ;

Broedel, SE ;

Clarke, J ;

Fernandez, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3694-3699

[6] Single-molecule study of transcriptional pausing and arrest by E-coli RNA polymerase [J].

Davenport, RJ ;

Wuite, GJL ;

Landick, R ;

Bustamante, C .

SCIENCE, 2000, 287 (5462) :2497-2500

[7] RESPONSE OF A PROTEIN-STRUCTURE TO CAVITY-CREATING MUTATIONS AND ITS RELATION TO THE HYDROPHOBIC EFFECT [J].

ERIKSSON, AE ;

BAASE, WA ;

ZHANG, XJ ;

HEINZ, DW ;

BLABER, M ;

BALDWIN, EP ;

MATTHEWS, BW .

SCIENCE, 1992, 255 (5041) :178-183

[8] SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS [J].

FINER, JT ;

SIMMONS, RM ;

SPUDICH, JA .

NATURE, 1994, 368 (6467) :113-119

[9]

Huang SH, 1999, NAT STRUCT BIOL, V6, P1132

[10] Folding-unfolding transitions in single titin molecules characterized with laser tweezers [J].

Kellermayer, MSZ ;

Smith, SB ;

Granzier, HL ;

Bustamante, C .

SCIENCE, 1997, 276 (5315) :1112-1116

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