Bone Morphogenetic Proteins: A critical review

被引：600

作者：

Bragdon, Beth ^{[1
,2
]}

Moseychuk, Oleksandra ^{[1
]}

Saldanha, Sven ^{[3
]}

King, Daniel ^{[1
]}

Julian, Joanne ^{[1
]}

Nohe, Anja ^{[1
]}

机构：

[1] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA

[2] Univ Maine, Dept Mol & Biomed Sci, Orono, ME 04469 USA

[3] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA

来源：

CELLULAR SIGNALLING | 2011年 / 23卷 / 04期

关键词：

Bone Morphogenetic Proteins; BMP receptors; Extracellular matrix; OSTEOBLASTIC CELL-DIFFERENTIATION; RECEPTOR-ASSOCIATED MOLECULE; PROCOLLAGEN C-PROTEINASE; FACTOR-BETA SUPERFAMILY; KAPPA-B ACTIVATION; TGF-BETA; SIGNALING PATHWAYS; BMP RECEPTOR; TWISTED-GASTRULATION; II RECEPTOR;

D O I：

10.1016/j.cellsig.2010.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily. To date over 20 members have been identified in humans with varying functions during processes such as embryogenesis, skeletal formation, hematopoesis and neurogenesis. Though their functions have been identified, less is known regarding levels of regulation at the extracellular matrix, membrane surface, and receptor activation. Further, current models of activation lack the integration of these regulatory mechanisms. This review focuses on the different levels of regulation, ranging from the release of BMPs into the extracellular components to receptor activation for different BMPs. It also highlights areas in research that is lacking or contradictory. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：609 / 620

页数：12

共 213 条

[1]

Crossveinless-2 is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning [J].