Bone morphogenetic proteins in orthopaedic surgery

被引：155

作者：

Axelrad, T. William ^{[1
]}

Einhorn, Thomas A. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Dept Orthopaed Surg, Boston, MA USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 5-6期

关键词：

BMP; Heterotopic ossification; OP-1; TGFbeta; Nonunion; ILIAC-CREST AUTOGRAFT; FACTOR-BETA SUPERFAMILY; OPEN TIBIAL FRACTURES; OP-1 PUTTY RHBMP-7; POSTEROLATERAL LUMBAR ARTHRODESIS; ANTERIOR CERVICAL DISKECTOMY; DIFFERENTIATION FACTOR-9; OSTEOGENIC PROTEIN-1; SIGNAL-TRANSDUCTION; RANDOMIZED-TRIAL;

D O I：

10.1016/j.cytogfr.2009.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bone healing is a predictable process that has a high rate of success. For some patients, and in certain clinical settings, this process can be delayed or completely inhibited. This leads to significant morbidity and may also result in time lost from work, costs related to prolonged medical treatment, and continued pain at the site of nonunion or failed spinal fusion. Several growth factors, specifically BMP-2 and BMP-7, have been approved in several Countries for specific indications. The use of these products and potential complications of their use are reviewed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：481 / 488

页数：8

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