Synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation

被引：411

作者：

Groebke, K ^{[1
]}

Weber, L ^{[1
]}

Mehlin, F ^{[1
]}

机构：

[1] Hoffmann La Roche Ag, Preclin Res, Div Pharma, CH-4070 Basel, Switzerland

来源：

SYNLETT | 1998年 / 06期

关键词：

combinatorial chemistry; multicomponent condensation; Ugi reaction; heterobicyclic compounds; imidazopyridines; imidazopyrazines; imidazopyrimidines;

D O I：

10.1055/s-1998-1721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel three-component, one-pot condensation yielding 3-amino-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyrimidines from aldehydes, isonitriles and 2-amino-pyridine, 2-amino-pyrazine or 2-amino-pyrimidine is described.

引用

页码：661 / +

页数：4

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