The establishment and maintenance of lymphocyte identity through gene silencing

被引:53
作者
Smale, ST [1 ]
机构
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
关键词
D O I
10.1038/ni0703-607
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cell identity is determined by selective gene activation and by the maintenance of other regulated genes in a silent state. Although activation mechanisms have been dissected in considerable depth, great strides towards an understanding of the molecular control of gene silencing have been made only recently. Molecular hallmarks of silent chromatin and proteins involved in its assembly and maintenance have been identified through genetic, cytological and biochemical studies in a variety of organisms. Immunologists are now beginning to use this knowledge to elucidate mechanisms underlying cell fate decisions and key developmental steps. This review surveys the current knowledge of gene silencing, with an emphasis on studies in lymphocytes that are advancing our general understanding of silencing mechanisms during development.
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收藏
页码:607 / 615
页数:9
相关论文
共 119 条
[1]   Negative regulation of CD4 gene expression by a HES-1-c-Myb complex [J].
Allen, RD ;
Kim, HK ;
Sarafova, SD ;
Siu, G .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (09) :3071-3082
[2]  
Annunziato AT, 2000, GENE EXPRESSION, V9, P37
[3]  
Bae SC, 1999, HISTOL HISTOPATHOL, V14, P1213, DOI 10.14670/HH-14.1213
[4]   Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].
Bannister, AJ ;
Zegerman, P ;
Partridge, JF ;
Miska, EA ;
Thomas, JO ;
Allshire, RC ;
Kouzarides, T .
NATURE, 2001, 410 (6824) :120-124
[5]   DNA methylation patterns and epigenetic memory [J].
Bird, A .
GENES & DEVELOPMENT, 2002, 16 (01) :6-21
[6]  
BIRD A, 1999, CELL, V7, P889
[7]   Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division [J].
Brown, KE ;
Baxter, J ;
Graf, D ;
Merkenschlager, M ;
Fisher, AG .
MOLECULAR CELL, 1999, 3 (02) :207-217
[8]   Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin [J].
Brown, KE ;
Guest, SS ;
Smale, ST ;
Hahm, K ;
Merkenschlager, M ;
Fisher, AG .
CELL, 1997, 91 (06) :845-854
[9]  
BROWN KL, 1998, RRD INORG CHEM, V1, P1
[10]   Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process [J].
Bruniquel, D ;
Schwartz, RH .
NATURE IMMUNOLOGY, 2003, 4 (03) :235-240