Pioneer axon guidance by UNC-129, a C-elegans TGF-β

被引：186

作者：

Colavita, A

Krishna, S

Zheng, H

Padgett, RW

Culotti, JG

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

[3] Rutgers State Univ, Waksman Inst, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

[4] Rutgers State Univ, Canc Inst New Jersey, Piscataway, NJ 08854 USA

来源：

SCIENCE | 1998年 / 281卷 / 5377期

关键词：

D O I：

10.1126/science.281.5377.706

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The unc-129 gene, Like the unc-6 netrin gene, is required.to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

引用

页码：706 / 709

页数：6

共 27 条

[1]

[Anonymous], [No title captured]

[2] UNC-40, a C-elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues [J].