Pioneer axon guidance by UNC-129, a C-elegans TGF-β

被引：186

作者：

Colavita, A

Krishna, S

Zheng, H

Padgett, RW

Culotti, JG

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

[3] Rutgers State Univ, Waksman Inst, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

[4] Rutgers State Univ, Canc Inst New Jersey, Piscataway, NJ 08854 USA

来源：

SCIENCE | 1998年 / 281卷 / 5377期

关键词：

D O I：

10.1126/science.281.5377.706

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The unc-129 gene, Like the unc-6 netrin gene, is required.to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

引用

收藏

页码：706 / 709

页数：6

相关论文

共 27 条

[11] Transforming growth factor beta 1: Three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2 [J].

Hinck, AP ;

Archer, SJ ;

Qian, SW ;

Roberts, AB ;

Sporn, MB ;

Weatherbee, JA ;

Tsang, MLS ;

Lucas, R ;

Zhang, BL ;

Wenker, J ;

Torchia, DA .

BIOCHEMISTRY, 1996, 35 (26) :8517-8534

[12] Deleted in Colorectal Cancer (DCC) encodes a netrin receptor [J].

KeinoMasu, K ;

Masu, M ;

Hinck, L ;

Leonardo, ED ;

Chan, SSY ;

Culotti, JG ;

TessierLavigne, M .

CELL, 1996, 87 (02) :175-185

[13] THE TGF-BETA SUPERFAMILY - NEW MEMBERS, NEW RECEPTORS, AND NEW GENETIC TESTS OF FUNCTION IN DIFFERENT ORGANISMS [J].

KINGSLEY, DM .

GENES & DEVELOPMENT, 1994, 8 (02) :133-146

[14] Vertebrate homologues of C-elegans UNC-5 are candidate netrin receptors [J].

Leonardo, ED ;

Hinck, L ;

Masu, M ;

KeinoMasu, K ;

Ackerman, SL ;

TessierLavigne, M .

NATURE, 1997, 386 (6627) :833-838

[15] UNC-5, A TRANSMEMBRANE PROTEIN WITH IMMUNOGLOBULIN AND THROMBOSPONDIN TYPE-1 DOMAINS, GUIDES CELL AND PIONEER AXON MIGRATIONS IN C-ELEGANS [J].

LEUNGHAGESTEIJN, CY ;

SPENCE, AM ;

STERN, BD ;

ZHOU, YW ;

SU, MW ;

HEDGECOCK, EM ;

CULOTTI, JG .

CELL, 1992, 71 (02) :289-299

[16] EFFICIENT GENE-TRANSFER IN C-ELEGANS - EXTRACHROMOSOMAL MAINTENANCE AND INTEGRATION OF TRANSFORMING SEQUENCES [J].

MELLO, CC ;

KRAMER, JM ;

STINCHCOMB, D ;

AMBROS, V .

EMBO JOURNAL, 1991, 10 (12) :3959-3970

[17]

NASH B, UNPUB

[18]

OKKEMA PG, 1993, GENETICS, V135, P385

[19] CHARACTERIZATION OF MUTATED TRANSFORMING GROWTH FACTOR-BETA-S WHICH POSSESS UNIQUE BIOLOGICAL PROPERTIES [J].

QIAN, SW ;

BURMESTER, JK ;

SUN, PD ;

HUANG, A ;

OHLSEN, DJ ;

SUARDET, L ;

FLANDERS, KC ;

DAVIES, D ;

ROBERTS, AB ;

SPORN, MB .

BIOCHEMISTRY, 1994, 33 (40) :12298-12304

[20] Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components [J].

Savage, C ;

Das, P ;

Finelli, AL ;

Townsend, SR ;

Sun, CY ;

Baird, SE ;

Padgett, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) :790-794