Two-voxel localization sequence for in vivo two-dimensional homonuclear correlation spectroscopy

被引:11
作者
Delmas, F [1 ]
Beloeil, JC
van der Sanden, BPJ
Nicolay, K
Gillet, B
机构
[1] CNRS, Inst Chim Subst Nat, Lab RMN Biol, F-91198 Gif Sur Yvette, France
[2] Univ Med Ctr, Image Sci Inst, Dept Expt In Vivo NMR, Utrecht, Netherlands
关键词
two-dimensional correlation H-1 MRS; multivoxel localization; Hadamard encoding; rat brain; cerebral metabolites;
D O I
10.1006/jmre.2000.2280
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The combination of localized 2D H-1 MR correlation spectroscopy and Hadamard encoding allows the simultaneous acquisition of multiple volumes of interest without an increase in the experimental duration, compared to single-voxel acquisition. In the present study, 2D correlation spectra were acquired simultaneously within 20 to 40 min in two voxels located in each hemisphere of the rat brain. An intervoxel distance of 20% of the voxel size was sufficient to limit spatial contamination. The following cerebral metabolites gave detectable crosspeaks: N-acetylaspartate, the glutamate/glutamine pool, aspartate, phosphoethanolamine, glucose, glutathione, taurine, myo-inositols, lactate, threonine, gamma -aminobutyric acid, and alanine. Most of the metabolites were measured without contamination of other resonances. (C) 2001 Academic Press.
引用
收藏
页码:119 / 125
页数:7
相关论文
共 38 条
[1]   ASSIGNMENT OF RESONANCES IN THE H-1 SPECTRUM OF RAT-BRAIN BY 2-DIMENSIONAL SHIFT CORRELATED AND J-RESOLVED NMR-SPECTROSCOPY [J].
BEHAR, KL ;
OGINO, T .
MAGNETIC RESONANCE IN MEDICINE, 1991, 17 (02) :285-303
[2]   HADAMARD SPECTROSCOPIC IMAGING (HSI) FOR MULTIVOLUME LOCALIZATION [J].
BOLINGER, L ;
LEIGH, JS .
JOURNAL OF MAGNETIC RESONANCE, 1988, 80 (01) :162-167
[3]  
Bottomley P., 1984, Patent, Patent No. [4480228, 4,480,228]
[4]   PRACTICAL APPLICATIONS OF CHEMICAL-SHIFT IMAGING [J].
BROWN, TR .
NMR IN BIOMEDICINE, 1992, 5 (05) :238-243
[5]   NMR CHEMICAL-SHIFT IMAGING IN 3 DIMENSIONS [J].
BROWN, TR ;
KINCAID, BM ;
UGURBIL, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3523-3526
[6]  
Brulatout S, 1996, J NEUROCHEM, V66, P2491
[7]  
Cunningham CH, 1999, MAGNET RESON MED, V42, P577, DOI 10.1002/(SICI)1522-2594(199909)42:3<577::AID-MRM21>3.0.CO
[8]  
2-E
[9]  
de Graaf RA, 1999, MAGN RESON MED, V41, P1136, DOI 10.1002/(SICI)1522-2594(199906)41:6<1136::AID-MRM9>3.0.CO
[10]  
2-G