The angiogenic process as a therapeutic target in cancer

被引：96

作者：

Bridges, Esther M. ^{[1
]}

Harris, Adrian L. ^{[1
]}

机构：

[1] Univ Oxford, Mol Oncol Labs, Sect Med Oncol, Weatherall Inst Mol Med,Dept Oncol,John Radciffe, Oxford OX3 9DS, England

来源：

BIOCHEMICAL PHARMACOLOGY | 2011年 / 81卷 / 10期

关键词：

Anti-angiogenic therapy; Bevacizumab; Biomarkers; Resistance; ENDOTHELIAL-GROWTH-FACTOR; ADVANCED BREAST-CANCER; PACLITAXEL PLUS BEVACIZUMAB; TYROSINE KINASE INHIBITOR; RENAL-CELL CARCINOMA; ANTI-VEGF THERAPY; TUMOR VASCULATURE; MOLECULAR-BASIS; COLORECTAL-CANCER; PROLONGS SURVIVAL;

D O I：

10.1016/j.bcp.2011.02.016

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Angiogenesis has emerged as a critical process for tumour progression. Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. The most prominent and characterised pro-angiogenic pathway is the vascular endothelial growth factor signalling pathway. This review will describe several inhibitors of angiogenesis currently in clinical trial and their various targets. Targeting pro-angiogenic pathways has improved outcome for many patients, however, the emerging problems with drug resistance with clinically approved angiogenic inhibitors will also be discussed in this review. It is hoped that identifying the causes of tumour re-growth and disease progression following treatment will enable future anti-angiogenic therapies to circumvent resistance. (C) 2011 Elsevier Inc. All rights reserved.

引用

收藏

页码：1183 / 1191

页数：9

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