Human antimicrobial proteins -: effectors of innate immunity

被引：79

作者：

Harder, Juergen ^{[1
]}

Glaeser, Regine ^{[1
]}

Schroeder, Jens-Michael ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Dept Dermatol, Clin Res Unit, D-24105 Kiel, Germany

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2007年 / 13卷 / 06期

关键词：

antimicrobial proteins; antimicrobial peptides; innate immunity; host defense; infectious diseases;

D O I：

10.1177/0968051907088275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We live in a world populated by an enormous number of micro-organisms. This necessitates the existence of highly effective mechanisms to control microbial growth. Through many research efforts, a chemical defense system based on the production of antimicrobial proteins (AMPS) has been identified. AMPS are endogenous, small proteins exhibiting antimicrobial activity against a wide variety of micro-organisms. The wide distribution of these molecules in the plant and animal kingdom reflects their biological significance. Various human AMPS show a potent effect on pathogenic micro-organisms including antibiotic-resistant bacteria. Thus, there is great interest in understanding the role of AMPS within innate immunity and evaluating their use and/or specific induction to fend off infections. In this review, we provide an overview of the characteristics of human AMPS and discuss examples where AMPS may be involved in the pathogenesis of infectious and inflammatory diseases.

引用

页码：317 / 338

页数：22

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