Genetic epidemiology 3 - Genetic association studies

被引：337

作者：

Cordell, HJ ^{[1
]}

Clayton, DG ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med Genet,Adenbrookes Hosp, Juvenile Diabet Res Fdn,Cambridge Inst Med Res, Wellcome Trust Diabet & Inflammat Lab, Cambridge CB2 2XY, England

来源：

LANCET | 2005年 / 366卷 / 9491期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(05)67424-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based designs, the need to account for different underlying genetic mechanisms, and the effect of population history. Association differs from linkage (covered elsewhere in this series) in that the alleles of interest will be the same across the whole population. As with other types of genetic epidemiological study, issues of design, statistical analysis, and interpretation are very important.

引用

页码：1121 / 1131

页数：11

共 115 条

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