Free radical reactions on soluble supports from ring-opening metathesis

被引：20

作者：

Enholm, EJ ^{[1
]}

Gallagher, ME ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 21期

关键词：

D O I：

10.1021/ol016632n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Free radical reactions were performed on soluble ring-opening metathesis (ROM) polymers. These polymers have high substrate loading, short reaction times, and the benefit of a facile purification. All reactions on these supports were obtained in good yields as white crystalline-like materials readily separated from tin byproducts.

引用

收藏

页码：3397 / 3399

页数：3

相关论文

共 21 条

[1] ROMPGEL scavengers:: A high-loading supported anhydride for sequestering amines and hydrazines [J].

Arnauld, T ;

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zécri, FJ .

ORGANIC LETTERS, 2000, 2 (17) :2663-2666

[2] Polymer backbone disassembly: polymerisable templates and vanishing supports in high loading parallel synthesis [J].

Ball, CP ;

Barrett, AGM ;

Poitout, LF ;

Smith, ML ;

Thorn, ZE .

CHEMICAL COMMUNICATIONS, 1998, (22) :2453-2454

[3] A ROMPGEL-supported N-hydroxysuccinimide:: A host of acylations with minimal purification [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 2000, 2 (03) :261-264

[4] Horner-Emmons synthesis with minimal purification using ROMPGEL: A novel high-loading matrix for supported reagents [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 1999, 1 (04) :579-582

[5] Solid-phase intermolecular radical reactions 1. Sulfonyl radical addition to isolated alkenes and alkynes [J].

Caddick, S ;

Hamza, D ;

Wadman, SN .

TETRAHEDRON LETTERS, 1999, 40 (40) :7285-7288

[6] Synthesis and characterization of new ruthenium-based olefin metathesis catalysts coordinated with bidentate Schiff-base ligands [J].

Chang, S ;

Jones, L ;

Wang, CM ;

Henling, LM ;

Grubbs, RH .

ORGANOMETALLICS, 1998, 17 (16) :3460-3465

[7] THE DESIGN AND APPLICATION OF FREE-RADICAL CHAIN REACTIONS IN ORGANIC-SYNTHESIS .2. [J].

CURRAN, DP .

SYNTHESIS-STUTTGART, 1988, (07) :489-513

[8] An allylstannane reagent on non-cross-linked polystyrene support [J].

Enholm, EJ ;

Gallagher, ME ;

Moran, KM ;

Lombardi, JS ;

Schulte, JP .

ORGANIC LETTERS, 1999, 1 (05) :689-691

[9] Convenient catalytic free radical reductions of alkyl halides using an organotin reagent on non-cross-linked polystyrene support [J].

Enholm, EJ ;

Schulte, JP .

ORGANIC LETTERS, 1999, 1 (08) :1275-1277

[10]

Giese B., 1986, RADICALS ORGANIC SYN