Anti-alpha-enolase antibodies in pituitary disease

被引：45

作者：

Tanaka, S

Tatsumi, K

Takano, T

Murakami, Y

Takao, T

Yamakita, N

Tahara, S

Teramoto, A

Hashimoto, K

Kato, Y

Amino, N

机构：

[1] Osaka Univ, Dept Lab Med, Grad Sch Med D2, Suita, Osaka 5650871, Japan

[2] Shimane Med Univ, Dept Med, Div 1, Izumo, Shimane 6938501, Japan

[3] Kochi Med Sch, Dept Internal Med 2, Nankoku, Kochi 7838505, Japan

[4] Matsunami Gen Hosp, Dept Internal Med, Gifu 5016062, Japan

[5] Nippon Med Coll, Dept Neurosurg, Bunkyo Ku, Tokyo 1138603, Japan

来源：

ENDOCRINE JOURNAL | 2003年 / 50卷 / 06期

关键词：

autoantibody; enolase; lymphocytic hypophysitis; pituitary adenoma;

D O I：

10.1507/endocrj.50.697

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.

引用

页码：697 / 702

页数：6

共 26 条

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