Longitudinal changes in photopic OPs occurring with vigabatrin treatment

被引:20
作者
Morong, S
Westall, CA
Nobile, R
Buncic, JR
Logan, WJ
Panton, CM
Abdolell, M
机构
[1] Hosp Sick Children, Dept Ophthalmol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Paediat, Div Neurol, Toronto, ON M5S 1A1, Canada
[3] Univ Toronto, Hosp Sick Children, Res Inst, Brain & Behav Programme, Toronto, ON M5S 1A1, Canada
基金
加拿大健康研究院;
关键词
ERG; longitudinal; paediatric; vigabatrin;
D O I
10.1023/B:DOOP.0000005338.51554.e3
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: Vigabatrin (gamma-vinyl-GABA) is an antiepileptic drug successful in the management of infantile spasms. Photopic ERGs were tested in children followed longitudinally before and during vigabatrin treatment. Methods: Subjects were 26 infants (age range 1.5-24 months, median 7.6 months) on vigabatrin treatment who had been tested on multiple visits (two to four visits; mean, three visits). Eighteen of these were assessed initially before starting vigabatrin therapy and eight were assessed within 1 week of initiation of the drug. ERGs were recorded at 6-month intervals. Standard ISCEV protocol with Burian-Allen bipolar contact-lens electrodes (standard flash 2.0 cd.s/m(2)) was used. Although ISCEV standards were followed, a higher flash intensity (set at 3.6 cd.s/m(2)) was chosen for single-flash cone assessment to provide a better definition of OPs. Photopic OPs were divided into categories of early OPs and late OP (OP4). Responses were compared with age corrected limits extrapolated from our lab control database. Results: Results showed differential effects of vigabatrin on the summed early OP amplitudes versus the late OP (OP4) and cone b-wave amplitude. The early OPs showed significant decrease (p = 0.0005, repeated measures analysis of variance) after 6 months and remained decreased for the duration of treatment. There was no significant change seen in the late OP. The cone b-wave amplitude showed initial increase (p = 0.04) after 6 months, followed by a decrease after 18 months; a trend similar to that of the late OP. Conclusiom Early photopic OPs were disrupted more than the late OP, suggesting relative deficit in the ON (depolarizing) retinal pathways.
引用
收藏
页码:289 / 297
页数:9
相关论文
共 28 条
[21]   B-WAVE OF THE ELECTRORETINOGRAM - A REFLECTION OF ON BIPOLAR CELL-ACTIVITY [J].
STOCKTON, RA ;
SLAUGHTER, MM .
JOURNAL OF GENERAL PHYSIOLOGY, 1989, 93 (01) :101-122
[22]  
WACHTMEISTER L, 1978, INVEST OPHTH VIS SCI, V17, P1176
[23]  
WACHTMEISTER L, 1980, ACTA OPHTHALMOL, V58, P712
[24]   Oscillatory potentials in the retina: what do they reveal [J].
Wachtmeister, L .
PROGRESS IN RETINAL AND EYE RESEARCH, 1998, 17 (04) :485-521
[25]   Changes in the electroretinogram resulting from discontinuation of vigabatrin in children [J].
Westall, CA ;
Nobile, R ;
Morong, S ;
Buncic, JR ;
Logan, WJ ;
Panton, CM .
DOCUMENTA OPHTHALMOLOGICA, 2003, 107 (03) :299-309
[26]   Time courses for maturation of electroretinogram responses from infancy to adulthood - ERG responses mature at different ages [J].
Westall, CA ;
Panton, CM ;
Levin, AV .
DOCUMENTA OPHTHALMOLOGICA, 1999, 96 (04) :355-379
[27]   The Hospital for Sick Children, Toronto, longitudinal ERG study of children on vigabatrin [J].
Westall C.A. ;
Logan W.J. ;
Smith K. ;
Buncic J.R. ;
Panton C.M. ;
Abdolell M. .
Documenta Ophthalmologica, 2002, 104 (2) :133-149
[28]   MICROELECTRODE DEPTH STUDY OF THE ELECTRORETINOGRAPHIC OSCILLATORY POTENTIALS IN THE FROG RETINA [J].
YANAGIDA, T ;
KOSHIMIZU, M ;
KAWASAKI, K ;
YONEMURA, D .
DOCUMENTA OPHTHALMOLOGICA, 1987, 67 (04) :355-361