1,7-induction of chirality in Mukaiyama aldol reactions using π-allyltricarbonyliron lactone and lactam complexes as chiral templates

被引：15

作者：

Ley, SV ^{[1
]}

Cox, LR ^{[1
]}

Middleton, B ^{[1
]}

Worrall, JM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)01159-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mukaiyama aldol reactions of silyl enol ether-substituted pi-allyltricarbonyliron lactone and lactam complexes with aldehydes under BF3. OEt2 activation proceed with moderate to excellent diastereocontrol. The level of diastereocontrol is strongly affected by the nature of the endo substituent on the complex, seven carbon atoms distant from the reaction site. A detailed investigation of the reaction is presented and a model for the observed stereoselectivity proposed. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3515 / 3530

页数：16

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