Hypoxia-Inducible Factors in Physiology and Medicine

被引：2567

作者：

Semenza, Gregg L. ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Pediat,McKusick Nathans Inst, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Med,McKusick Nathans Inst Gen, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Oncol,McKusick Nathans Inst G, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Radiat Oncol,McKusick Nathans, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Radiat Oncol,McKusick Nathans, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn,Dept Biol Chem,McKusick Nathans In, Baltimore, MD 21205 USA

来源：

CELL | 2012年 / 148卷 / 03期

基金：

日本科学技术振兴机构; 美国国家卫生研究院;

关键词：

FACTOR-I; GENE-THERAPY; ANGIOGENIC CELLS; BINDING-SITES; KEY REGULATOR; DNA-BINDING; STEM-CELLS; HIF-1-ALPHA; EXPRESSION; MICE;

D O I：

10.1016/j.cell.2012.01.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.

引用

页码：399 / 408

页数：10

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