In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica

被引:283
作者
Shukla, A
Rasik, AM
Jain, GK
Shankar, R
Kulshrestha, DK
Dhawan, BN
机构
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
[2] Div Pharmacol, Lucknow 226001, Uttar Pradesh, India
[3] Div Pharmaceut, Lucknow 226001, Uttar Pradesh, India
[4] Ind Toxicol Res Ctr, Lucknow 226001, Uttar Pradesh, India
关键词
Centella asiatica; wound healing; angiogenesis; asiaticoside;
D O I
10.1016/S0378-8741(98)00141-X
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The activity of asiaticoside, isolated from Centella asiatica, has been studied in normal as well as delayed-type wound healing. In guinea pig punch wounds topical applications of 0.2% solution of asiaticoside produced 56% increase in hydroxyproline, 57% increase in tensile strength, increased collagen content and better epithelisation. In streptozotocin diabetic rats, where healing is delayed, topical application of 0.4% solution of asiaticoside over punch wounds increased hydroxyproline content, tensile strength, collagen content and epithelisation thereby facilitating the healing. Asiaticoside was active by the oral route also at 1 mg;kg dose in the guinea pig punch wound model. It promoted angiogenesis in the chick chorioallantoic membrane model at 40 mu g/disk concentration. These results indicate that asiaticoside exhibits significant wound healing activity in normal as well as delayed healing models and is the main active constituent of Centella asiatica. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码:1 / 11
页数:11
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