High-resolution analysis of the spatio-temporal activity patterns in rat olfactory bulb evoked by enantiomer odors

被引:16
作者
Lehmkuhle, MJ [1 ]
Normann, RA [1 ]
Maynard, EM [1 ]
机构
[1] Univ Utah, Dept Bioengn, Ctr Neural Interfaces, Salt Lake City, UT 84112 USA
关键词
electrophysiology; encoding; ensemble; mitral cells; multielectrode; population;
D O I
10.1093/chemse/28.6.499
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Understanding how mammals process olfactory stimuli has motivated the development of tools and techniques which permit the simultaneous study of finely structured spatial and temporal patterns of neural activity. A technique is described that uses an array of 32 penetrating microelectrodes implanted bilaterally into the dorsal aspect of rat olfactory bulb to investigate the responses of mitral and tufted neurons to stimulation with simple enantiomer odor pairs at a number of concentrations. It is shown that stable, simultaneous recordings from up to 49 single- and multi-units can be performed for periods of up to 14 h. We show that such odors evoke unique spatial and fast-temporal activity patterns which may subserve odor discrimination. This technique is extensible to other systems neuroscience investigations of olfactory sensory processing.
引用
收藏
页码:499 / 508
页数:10
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