The cell biology of cross-presentation and the role of dendritic cell subsets

被引：122

作者：

Lin, Ming-Lee ^{[1
]}

Zhan, Yifan ^{[1
]}

Villadangos, Jose A. ^{[1
]}

Lew, Andrew M. ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2008年 / 86卷 / 04期

关键词：

cross-presentation; cytosolic pathway; dendritic cells; resident; migratory;

D O I：

10.1038/icb.2008.3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell biology of cross-presentation is reviewed regarding exogenous antigen uptake, antigen degradation and entry into the major histocompatibility complex class I pathway. Whereas cross-presentation is not associated with enhanced phagocytic ability, certain receptors may favour uptake for cross-presentation for example mannose receptor for soluble glycoproteins. Perhaps, the defining property of the cross-presenting cell is some specialization in host machinery for handling and transport of antigen across organelles. Both cytosolic and vacuolar pathways are discussed. Which dendritic cell (DC) subset is the cross-presenting cell is explored. Cross-presentation is found within the CD8(+) subset resident in lymphoid organs. The role of other DC subsets (especially the migratory CD8(-) DC) and the route of antigen delivery are also discussed. Further consideration is given to antigen transfer between DC subsets and differential presentation to naive vs memory T cells.

引用

页码：353 / 362

页数：10

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