Slow clearance of human parvovirus B19 viremia following acute infection

被引:88
作者
Lindblom, A
Isa, A
Norbeck, O
Wolf, S
Johansson, B
Broliden, K
Tolfvenstam, T
机构
[1] Karolinska Univ Hosp, Karolinska Inst, Div Clin Virol, Dept Lab Med, SE-14186 Stockholm, Sweden
[2] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Infect Dis Unit,Ctr Mol Med, SE-14186 Stockholm, Sweden
关键词
D O I
10.1086/444503
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Parvovirus B19 is a common, clinically significant pathogen. Reassessment of the viral kinetics after acute infection showed that the virus is not rapidly cleared from healthy hosts, despite early resolution of symptoms. These findings challenge our current conception of the virus' pathogenesis and have implications for the management of the infection.
引用
收藏
页码:1201 / 1203
页数:3
相关论文
共 13 条
[1]   EXPERIMENTAL PARVOVIRAL INFECTION IN HUMANS [J].
ANDERSON, MJ ;
HIGGINS, PG ;
DAVIS, LR ;
WILLMAN, JS ;
JONES, SE ;
KIDD, IM ;
PATTISON, JR ;
TYRRELL, DAJ .
JOURNAL OF INFECTIOUS DISEASES, 1985, 152 (02) :257-265
[2]   Evaluation of a real-time PCR assay using the LightCycler System for detection of parvovirus B19 DNA [J].
Buller, RS ;
Storch, G .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (07) :3326-3328
[3]   Quantitative evidence for persistence of human parvovirus B19 DNA in an immunocompetent individual [J].
Cassinotti, P ;
Siegl, G .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (11) :886-887
[4]   Calibrated real-time PCR for evaluation of parvovirus B19 viral load [J].
Gallinella, G ;
Bonvicini, F ;
Filippone, C ;
Delbarba, S ;
Manaresi, E ;
Zerbini, M ;
Musiani, M .
CLINICAL CHEMISTRY, 2004, 50 (04) :759-762
[5]   Human parvovirus B19 [J].
Heegaard, ED ;
Brown, KE .
CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (03) :485-+
[6]  
ISA A, IN PRESS PLOS MED
[7]   Rapid effector function in CD8(+) memory T cells [J].
Lalvani, A ;
Brookes, R ;
Hambleton, S ;
Britton, WJ ;
Hill, AVS ;
McMichael, AJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (06) :859-865
[8]  
Lundqvist A, 1999, SCAND J INFECT DIS, V31, P11, DOI 10.1080/00365549950161817
[9]   Diagnosis and quantitative evaluation of parvovirus B19 infections by real-time PCR in the clinical laboratory [J].
Manaresi, E ;
Gallinella, G ;
Zuffi, E ;
Bonvicini, F ;
Zerbini, M ;
Musiani, M .
JOURNAL OF MEDICAL VIROLOGY, 2002, 67 (02) :275-281
[10]   PARVOVIRUS B19 CLEARANCE FROM PERIPHERAL-BLOOD AFTER ACUTE INFECTION [J].
MUSIANI, M ;
ZERBINI, M ;
GENTILOMI, G ;
PLAZZI, M ;
GALLINELLA, G ;
VENTUROLI, S .
JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (05) :1360-1363