Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside

被引:110
作者
Li, Xinming [1 ]
Kuang, Yi [1 ]
Shi, Junfeng [1 ]
Gao, Yuan [1 ]
Lin, Hsin-Chieh [1 ]
Xu, Bing [1 ]
机构
[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA
关键词
SOLID-PHASE SYNTHESIS; ENZYMATIC FORMATION; CIRCULAR-DICHROISM; GENE-TRANSFER; PEPTIDES; NANOFIBERS; COMPLEX; DESIGN; WATER; SUPERSTRUCTURES;
D O I
10.1021/ja208456k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
引用
收藏
页码:17513 / 17518
页数:6
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