Synthetic and spectroscopic investigations of N(4)-substituted isatin thiosemicarbazones and their copper(II) complexes

A series of N(4)-substituted thiosemicarbazones of isatin were synthesized and their copper(II) complexes prepared from copper(II) chloride. X-ray crystal structures of two of the thiosemicarbazones, isatin 3-(hexamethylenimylthiosemicarbazone) and isatin 3-(N(4)-ethylthiosemicarbazone), have been solved and are compared with a previously published structure of isatin 3-(N(4)-p-tolythiosemicarbazone). The coordination chemistry of the copper(II) complexes of these and other isatin thiosemicarbazones is reported and discussed. Copyright (C) 1996 Elsevier Science Ltd