Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

被引：131

作者：

Beulens, Joline W. J. ^{[1
,2
]}

van der A, Daphne L. ^{[3
]}

Grobbee, Diederick E. ^{[1
]}

Sluijs, Ivonne ^{[1
]}

Spijkerman, Annemieke M. W. ^{[2
]}

van der Schouw, Yvonne T. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Natl Inst Publ Hlth & Environm, Ctr Prevent & Hlth Serv Res, NL-3720 BA Bilthoven, Netherlands

[3] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

来源：

DIABETES CARE | 2010年 / 33卷 / 08期

关键词：

VITAMIN-K; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; OLDER MEN; WOMEN; OSTEOCALCIN; MARKERS; SUPPLEMENTATION; QUESTIONNAIRE; VALIDITY;

D O I：

10.2337/dc09-2302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% Cl 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-mu g increment in the multivariate model. CONCLUSIONS This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.

引用

页码：1699 / 1705

页数：7

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