Efficient synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones catalyzed by dodecylbenzenesulfonic acid in aqueous media under ultrasound irradiation

被引：58

作者：

Chen, Bao-Hua ^{[1
,2
]}

Li, Ji-Tai ^{[1
]}

Chen, Guo-Feng ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[2] Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China

来源：

ULTRASONICS SONOCHEMISTRY | 2015年 / 23卷

关键词：

2,3-Dihydroquinazolin-4(1H)-one; Catalysis; Condensation; Aqueous media; One-pot synthesis; Ultrasound irradiation; POT 3-COMPONENT SYNTHESIS; SURFACTANT-COMBINED CATALYST; SOLVENT-FREE CONDITIONS; ORGANIC-REACTIONS; REUSABLE CATALYST; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; DERIVATIVES; WATER; ANTAGONISTS; INHIBITORS;

D O I：

10.1016/j.ultsonch.2014.08.024

中图分类号：

O42 [声学];

学科分类号：

070206 [声学];

摘要：

Synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-one derivatives catalyzed by dodecylbenzenesulfonic acid was carried out in 80-92% yields at 40-42 degrees C within 1-2 h in aqueous media via one-pot three-component condensation of isatoic anhydride, aromatic aldehyde and amine under ultrasound irradiation. Convenient work-up procedures, mild reaction conditions, avoiding the use of organic solvents, and friendly to environment are the salient features of this protocol. (C) 2014 Elsevier B.V. All rights reserved.

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收藏

页码：59 / 65

页数：7

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