Multicomponent Synthesis of 1,2,3-Triazoles in Water Catalyzed by Copper Nanoparticles on Activated Carbon

被引：218

作者：

Alonso, Francisco ^{[1
,2
]}

Moglie, Yanina ^{[1
,2
]}

Radivoy, Gabriel ^{[3
]}

Yus, Miguel ^{[1
,2
]}

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain

[2] Univ Alicante, Inst Sintesis Organ, E-03080 Alicante, Spain

[3] Univ Nacl Sur, Inst Quim Sur INQUISUR CONICET, Dept Quim, RA-8000 Bahia Blanca, Buenos Aires, Argentina

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 18期

关键词：

click chemistry; copper nanoparticles; cycloaddition; heterogeneous catalysis; triazoles; water; ONE-POT SYNTHESIS; CLICK CHEMISTRY; TERMINAL ALKYNES; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; REGIOSELECTIVE SYNTHESIS; REUSABLE CATALYST; IN-SITU; 1,3-DIPOLAR CYCLOADDITIONS; SUPPORTED COPPER(I); MEDICINAL CHEMISTRY;

D O I：

10.1002/adsc.201000637

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Copper nanoparticles on activated carbon have been found to effectively catalyze the multicomponent synthesis of 1,2,3-triazoles from different azide precursors, such as organic halides, diazonium salts, anilines and epoxides in water. The first one-pot transformation of an olefin into a triazole is also described. The catalyst is easy to prepare, very versatile and reusable at a low copper loading.

引用

页码：3208 / 3214

页数：7

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