Synthesis of substituted P-stereogenic vinylphosphine oxides by olefin cross-metathesis

被引：53

作者：

Demchuk, OM

Pietrusiewicz, KM

Michrowska, A

Grela, K

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

[2] Marie Curie Sklodowska Univ, Dept Organ Chem, PL-20614 Lublin, Poland

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol035011m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Substituted vinylphosphine oxides have been prepared in good yield and exclusive (E)-olefin selectivity via olefin cross-metathesis using Grubbs and Hoveyda-type ruthenium catalysts. In addition, metathesis of chiral vinylphosphine oxides proceeds without racemization of the phosphorus chirality center, providing easy access to functionalized chiral nonracemic (E)-alkenylphosphine oxides.

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页码：3217 / 3220

页数：4

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