Synthesis of symmetrical trisubstituted olefins by cross metathesis

被引：169

作者：

Chatterjee, AK ^{[1
]}

Sanders, DP ^{[1
]}

Grubbs, RH ^{[1
]}

机构：

[1] CALTECH, Arnold & Mabel Beckman Lab Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 11期

关键词：

D O I：

10.1021/ol0259793

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Trisubstituted alkenes have been prepared via intermolecular olefin cross-metathesis (CM) between alpha-olefins and symmetrically 1,1-disubstituted olefins using an imidazolylidene ruthenium benzylidene complex. Of particular interest is the synthesis of isoprenoid/prenyl groups by a simple solvent-free CM reaction with isobutylene. In addition, prenyl groups can also be installed by a cross-metathesis of 2-methyl-2-butene with a variety of alpha-olefins at room temperature with low catalyst loadings.

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页码：1939 / 1942

页数：4

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