Cytotoxic labdane diterpenoids from Croton oblongifolius

被引：44

作者：

Roengsumran, S ^{[1
]}

Petsom, A

Kuptiyanuwat, N

Vilaivan, T

Ngamrojnavanich, N

Chaichantipyuth, C

Phuthong, S

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Inst Biotechnol & Genet Engn, Bangkok 10330, Thailand

来源：

PHYTOCHEMISTRY | 2001年 / 56卷 / 01期

关键词：

Croton oblongifolius; Euphorbiaceae; labdane; diterpenoid; cytotoxicity;

D O I：

10.1016/S0031-9422(00)00358-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)- 14-triene, 3-acetoxy-2-hydroxy-labda-8(17).12(E)-14-triene, and 2,3-dihydroxy-labda-8( 17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：103 / 107

页数：5

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