Efficient enantiomeric resolution via introduction of a fluorous tag as a resolving reagent with β-cyclodextrin columns:: model study on fluorinated O-acetylmandelate and ibuprofen amide

被引：10

作者：

Mitsuzawa, H ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期

关键词：

beta-cyclodextrin; liquid chromatography; optical resolution; fluorine chemistry;

D O I：

10.1016/S0040-4039(03)01538-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient enantiomeric resolution of racemates is performed by introduction of fluorous tags using beta-cyclodextrin columns. Selection of appropriate length of tag and mobile phase leads to an efficient resolution of racemates (fluorinated O-acetylmandelate and ibuprofen amide) by those columns. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6227 / 6230

页数：4

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