The role of cutaneous dendritic cells in the immunopathogenesis of atopic dermatitis

被引：14

作者：

Banfield, CC ^{[1
]}

Callard, RE

Harper, JI

机构：

[1] Hinchingbrooke Hosp, Dept Dermatol, Huntingdon PE18 8NT, England

[2] Inst Child Hlth, London WC1 3JH, England

[3] Great Ormond St Hosp Sick Children, London WC1 3JH, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2001年 / 144卷 / 05期

关键词：

atopic dermatitis; atopy; cytokines; dendritic cells; Langerhans cells; T cells;

D O I：

10.1046/j.1365-2133.2001.04179.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We review the immunology of atopic dermatitis (AD) and focus attention on the role of cutaneous dendritic cells. AD is a complex immune-mediated skin disorder characterized by the recruitment of both CD4+ and CD8+ T cells into the skin. T-helper (Th) 2-type cytokines are dominant in acute AD skin, while both Th1- and Th2-type cytokines are present in chronic AD. Cutaneous dendritic cells, which are present in increased numbers within AD skin, are believed to play a key part in the activation of T cells in the skin. They may also help to determine the pattern of cytokines produced by activated effector T cells.

引用

页码：940 / 946

页数：7

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