METHOX:: A new pyridine N-oxide organocatalyst for the asymmetric allylation of aldehydes with allyltrichlorosilanes

被引：137

作者：

Malkov, AV ^{[1
]}

Bell, M ^{[1
]}

Castelluzzo, F ^{[1
]}

Kocovsky, P ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, WestChem, Glasgow G12 8QQ, Lanark, Scotland

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 15期

关键词：

D O I：

10.1021/ol050972h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylation of aromatic aldehydes with allyltrichlorosilane is catalyzed by the new terpene-derived pyridine N-oxide (+)-METHOX (<= 5 mol %) in MeCN with high enantioselectivities (<= 96% ee) and conversion rates; this catalyst retains high selectivity even at room temperature.

引用

页码：3219 / 3222

页数：4

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