Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

被引：21

作者：

Caminos, Jorge E. ^{[1
,3
,4
,5
]}

Bravo, Susana B. ^{[1
]}

Gonzalez, C. Ruth ^{[1
]}

Garces, Maria F. ^{[1
,3
,4
]}

Cepeda, Libia A. ^{[3
,4
]}

Gonzalez, Adriana C. ^{[3
,4
]}

Cordido, Fernando ^{[5
]}

Lopez, Miguel ^{[1
,2
]}

Dieguez, Carlos ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Sch Med, Dept Physiol, Santiago De Compostela, Spain

[2] Inst Salud Carlos III, CIBER Obes & Nutr, Santiago De Compostela, Spain

[3] Univ Nacl Colombia, Fac Med, Dept Physiol, Bogota, Colombia

[4] Univ Nacl Colombia, Fac Med, Genet Inst, Bogota, Colombia

[5] Hosp Juan Canalejo, Dept Endocrine, La Coruna, Spain

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2008年 / 6卷 / 1期

关键词：

D O I：

10.1186/1477-7827-6-14

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Neuropeptide Y ( NPY), agouti related peptide ( AgRP), cocaine and amphetamine-regulated transcript ( CART) and melanocortins, the products of the proopiomelanocortin ( POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. Methods: In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Results: Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. Conclusion: These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.

引用

页数：6

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