A new antitumor antibiotic, BE-19412A, produced by a Streptomycete

被引：5

作者：

Tsukamoto, M ^{[1
]}

Nakajima, S ^{[1
]}

Arakawa, H ^{[1
]}

Sugiura, Y ^{[1
]}

Suzuki, H ^{[1
]}

Hirayama, M ^{[1
]}

Kamiya, S ^{[1
]}

Teshima, Y ^{[1
]}

Kondo, H ^{[1
]}

Kojiri, K ^{[1
]}

Suda, H ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Exploratory Res Labs, Tsukuba, Ibaraki 3002611, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 10期

关键词：

D O I：

10.7164/antibiotics.51.908

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF, mice bearing i.p. implanted Ehrlich carcinoma cells.

引用

页码：908 / 914

页数：7

共 8 条

[1] ED-110, A NOVEL INDOLOCARBAZOLE, PREVENTS THE GROWTH OF EXPERIMENTAL-TUMORS IN MICE [J].

ARAKAWA, H ;

IGUCHI, T ;

YOSHINARI, T ;

KOJIRI, K ;

SUDA, H ;

OKURA, A .

JAPANESE JOURNAL OF CANCER RESEARCH, 1993, 84 (05) :574-581

[2] A NEW MACROCYCLIC LACTAM ANTIBIOTIC, BE-14106 .1. TAXONOMY, ISOLATION, BIOLOGICAL-ACTIVITY AND STRUCTURAL ELUCIDATION [J].

KOJIRI, K ;

NAKAJIMA, S ;

SUZUKI, H ;

KONDO, H ;

SUDA, H .

JOURNAL OF ANTIBIOTICS, 1992, 45 (06) :868-874

[3] Structure of ericamycin having a 2-azahexaphene ring system [J].

Kondo, S ;

Ikeda, Y ;

Ikeda, D ;

Nishizuka, T ;

Gomi, S .

JOURNAL OF ANTIBIOTICS, 1998, 51 (02) :232-234

[4] PROTON CARBON NOE DIFFERENCE SPECTROSCOPY STUDIES OF CARBON MICROENVIRONMENTS, INTERNUCLEAR DISTANCES, AND HYDROGEN-BONDING IN RIFAMYCIN-S [J].

NICCOLAI, N ;

ROSSI, C ;

BRIZZI, V ;

GIBBONS, WA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (19) :5732-5733

[5] THE UTILIZATION OF CARBON COMPOUNDS BY SOME ACTINOMYCETALES AS AN AID FOR SPECIES DETERMINATION [J].

PRIDHAM, TG ;

GOTTLIEB, D .

JOURNAL OF BACTERIOLOGY, 1948, 56 (01) :107-114

[6]

SHIRLING E. B., 1966, INT J SYST BACTERIOL, V16, P313

[7] GRADIENT SELECTION IN INVERSE HETERONUCLEAR CORRELATION SPECTROSCOPY [J].

WILLKER, W ;

LEIBFRITZ, D ;

KERSSEBAUM, R ;

BERMEL, W .

MAGNETIC RESONANCE IN CHEMISTRY, 1993, 31 (03) :287-292

[8]

YOSHINARI T, 1995, CANCER RES, V55, P1310

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