IL-6 and IGF-1 Signaling Within and Between Muscle and Bone: How Important is the mTOR Pathway for Bone Metabolism?

被引：67

作者：

Bakker, Astrid D. ^{[2
,3
]}

Jaspers, Richard T. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Lab Myol, MOVE Res Inst Amsterdam, Fac Human Movement Sci, NL-1081 BT Amsterdam, Netherlands

[2] Univ Amsterdam, Dept Oral Cell Biol, Acad Ctr Dent Amsterdam ACTA, NL-1081 LA Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, MOVE Res Inst Amsterdam, NL-1081 LA Amsterdam, Netherlands

来源：

CURRENT OSTEOPOROSIS REPORTS | 2015年 / 13卷 / 03期

关键词：

Osteocyte; Osteoblast; Myoblast; Hypertrophy; mTOR; Mechanical loading; Aging; Osteoporosis; GROWTH-FACTOR-I; MESENCHYMAL STEM-CELLS; PROMOTES OSTEOBLAST DIFFERENTIATION; HUMAN SKELETAL-MUSCLE; BINDING PROTEIN-BETA; OSTEOCLAST FORMATION; OSTEOGENIC DIFFERENTIATION; INTERLEUKIN (IL)-6; UBIQUITIN LIGASES; STIMULATES GROWTH;

D O I：

10.1007/s11914-015-0264-1

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Insulin-like growth factor 1 (IGF-1) and interleukin 6 (IL-6) play an important role in the adaptation of both muscle and bone to mechanical stimuli. Here, we provide an overview of the functions of IL-6 and IGF-1 in bone and muscle metabolism, and the intracellular signaling pathways that are well known to mediate these functions. In particular, we discuss the Akt/mammalian target of rapamycin (mTOR) pathway which in skeletal muscle is known for its key role in regulating the rate of mRNA translation (protein synthesis). Since the role of the mTOR pathway in bone is explored to a much lesser extent, we discuss what is known about this pathway in bone and the potential role of this pathway in bone remodeling. We will also discuss the possible ways of influencing IGF-1 or IL-6 signaling by osteocytes and the clinical implications of pharmacological or nutritional modulation of the Akt/mTOR pathway.

引用

页码：131 / 139

页数：9

共 92 条

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Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or Losartan [J].