Are β-acylaminoacrylates hydrogenated in the same way as α-acylaminoacrylates?

被引：39

作者：

Drexler, HJ

Baumann, W

Schmidt, T

Zhang, SL

Sun, AL

Spannenberg, A

Fischer, C

Buschmann, H

Heller, D

机构：

[1] Univ Rostock eV, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] Henan Normal Univ Xinxiang, Coll Chem & Environm Sci, Henan 453007, Peoples R China

[3] ESTEVE, Barcelona 08041, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 08期

关键词：

asymmetric catalysis; beta-amino acids; catalyst-substrate complexes; hydrogenation; reaction mechanisms;

D O I：

10.1002/anie.200461716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five catalyst-substrate complexes of the type [Rh(chiral ligand)(β-dehydroamino acid derivative)]BF4 were characterized for the first time by X-ray analysis (see example). Low-temperature NMR spectroscopy proved that three of these complexes are "major" substrate complexes, which lead to the main product in asymmetric hydrogenation, contrary to the known classical examples with analogous α-dehydroamino acid derivatives. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1184 / 1188

页数：5

共 39 条

[11] Large-scale computational modeling of [Rh(DuPHOS)]+-catalyzed hydrogenation of prochiral enamides:: Reaction pathways and the origin of enantioselection [J].