Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations

被引:525
作者
Anderson, JR
Armitage, JO
Weisenburger, DD
机构
[1] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Dept Prevent & Societal Med, Omaha, NE 68198 USA
[3] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA
关键词
epidemiology; geography; histologic subtypes; non-Hodgkin's lymphoma;
D O I
10.1023/A:1008265532487
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: There has been no previous systematic study of the distribution of the major subtypes of non-Hodgkin's lymphoma (NHL) across geographic regions, although there have been isolated reports of such differences. Design: As part of a clinical evaluation of the International Lymphoma Study Group (ILSG) classification of NHL, we classified 1378 NHLs from eight different geographic sites (Omaha, NE, USA; Vancouver, BC, Canada; Capetown, South Africa; London, England; Wurzburg/Gottingen, Germany; Lyon, France; Locarno/Bellinzona, Switzerland; and Hong Kong) using the ILSG classification. Results: Substantial differences were found in the distribution of the major subtypes of NHL across geographic regions (P < 0.0001). A greater percentage of follicular lymphoma was seen in North America, London and Capetown (31% versus 14% at other sites). Peripheral T-cell lymphoma was more common in London. Capetown and Hong Kong (9%) than elsewhere (3%). In Locarno/Bellinzona, higher percentages of mediastinal large B-cell lymphoma (9% versus 2% elsewhere) and mantle cell lymphoma (14% versus 6% elsewhere) were seen. Angiocentric nasal T-/NK-cell lymphoma was only seen in Hong Kong (8%) and Lyon (2%). Conclusions: Our study provides evidence that the distribution of NHL subtypes differs by geographic region. These findings suggest that geographical differences in etiologic or host factors may be responsible for the observed differences in the distribution of cases across NHL subtypes.
引用
收藏
页码:717 / 720
页数:4
相关论文
共 20 条
  • [11] 2-A
  • [12] Report of the workshop on nasal and related extranodal angiocentric T natural killer cell lymphomas - Definitions, differential diagnosis, and epidemiology
    Jaffe, ES
    Chan, JKC
    Su, IJ
    Frizzera, G
    Mori, S
    Feller, AC
    Ho, FCS
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (01) : 103 - 111
  • [13] Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: A multicenter study of 106 patients
    Lazzarino, M
    Orlandi, E
    Paulli, M
    Strater, J
    Klersy, C
    Gianelli, U
    Gargantini, L
    Rousset, MT
    Gambacorta, M
    Morra, E
    LavabreBertrand, T
    Magrini, U
    Manegold, C
    Bernasconi, C
    Moller, P
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (04) : 1646 - 1653
  • [14] MALIGNANT-LYMPHOMAS IN CHINESE - WHAT IS THE EAST-WEST DIFFERENCE
    NG, CS
    CHAN, JKC
    [J]. HUMAN PATHOLOGY, 1988, 19 (05) : 614 - 615
  • [15] OBAFUNWA JO, 1992, CENT AFR J MED, V38, P17
  • [16] ROSENBERG SA, 1982, CANCER, V49, P2112
  • [17] NON-HODGKINS-LYMPHOMAS IN ASIA
    SHIH, LY
    LIANG, DC
    [J]. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1991, 5 (05) : 983 - 1001
  • [18] MALIGNANT-LYMPHOMAS IN GABON (EQUATORIAL AFRICA) - A MORPHOLOGICAL-STUDY OF 72 CASES
    WALTER, PR
    KLOTZ, F
    ALFYGATTAS, T
    MINKOMIETOUA, D
    NGUEMBIMBINA, C
    [J]. HUMAN PATHOLOGY, 1991, 22 (10) : 1040 - 1043
  • [19] WRIGHT DH, 1990, NONHODGKINS LYMPHOMA, P122
  • [20] XU LZ, 1984, J NATL CANCER I, V73, P635