The role of inhibin B as a basal determinant of ovarian reserve

被引：31

作者：

Fiçicioglu, C ^{[1
]}

Kutlu, T ^{[1
]}

Demurbasoglu, S ^{[1
]}

Mulayim, B ^{[1
]}

机构：

[1] Zeynep Kamil Women & Childrens Hosp, Dept Assisted Reprod Technol, Istanbul, Turkey

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2003年 / 17卷 / 04期

关键词：

D O I：

10.1080/713603292

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our objective was to compare inhibin B and conventional basal determinants in designating the ovarian reserve in patients receiving assisted reproductive treatment. A total of 58 women, aged 19-47 years, who were accepted for assested reproductive treatment at the Zeynep Kamil Women and Children's Hospital, Department of Assisted Reproductive Technologies, were included in the study. The age, body mass index, basal levels of follicle stimulating hormone, estradiol and inhibin B, volume of the ovary and number of antral follicles were compared prospectively. When the number of oocytes collected was greater than or equal to 5, this was accepted as a sufficient ovarian response. Serum inhibin B (cut-off) level 56 pg/ml), as a basal determinant of ovarian reserve, had the highest sensitivity (81%) and specificity (81%). The usefulness of serum inhibin B measurement as a basal determinant of ovarian reserve is supported.

引用

页码：287 / 293

页数：7

共 20 条

[1] Diminished alpha-inhibin messenger ribonucleic acid in in vitro fertilization-embryo transfer poor responders reflects declining follicle reserve [J].

Burns, WN ;

Oktay, KH ;

Tekmal, RR ;

Nelson, JF ;

Schenken, RS .

FERTILITY AND STERILITY, 1996, 65 (02) :394-399

[2] Inhibin-B as a test of ovarian reserve for infertile women [J].

Corson, SL ;

Gutmann, J ;

Batzer, FR ;

Wallace, H ;

Klein, N ;

Soules, MR .

HUMAN REPRODUCTION, 1999, 14 (11) :2818-2821

[3] Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome [J].

Creus, M ;

Peñarrubia, J ;

Fábregues, F ;

Vidal, E ;

Carmona, F ;

Casamitjana, R ;

Vanrell, JA ;

Balasch, J .

HUMAN REPRODUCTION, 2000, 15 (11) :2341-2346

[4] Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle [J].

Dzik, A ;

Lambert-Messerlian, G ;

Izzo, VM ;

Soares, JB ;

Pinotti, JA ;

Seifer, DB .

FERTILITY AND STERILITY, 2000, 74 (06) :1114-1117

[5] Relationship between serum inhibin A and B and ovarian follicle development after a daily fixed dose administration of recombinant follicle-stimulating hormone [J].

Eldar-Geva, T ;

Robertson, DM ;

Cahir, N ;

Groome, N ;

Gabbe, MP ;

Maclachlan, V ;

Healy, DL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (02) :607-613

[6] Serum inhibin B levels measured early during FSH administration for IVF may be of value in predicting the number of oocytes to be retrieved in normal and low responders [J].

Eldar-Geva, T ;

Margalioth, EJ ;

Ben-Chetrit, A ;

Gal, M ;

Robertson, DM ;

Healy, DL ;

Diamant, YZ ;

Spitz, IM .

HUMAN REPRODUCTION, 2002, 17 (09) :2331-2337

[7] EXOGENOUS FOLLICLE-STIMULATING-HORMONE OVARIAN RESERVE TEST (EFORT) - A SIMPLE AND RELIABLE SCREENING-TEST FOR DETECTING POOR RESPONDERS IN IN-VITRO FERTILIZATION [J].

FANCHIN, R ;

DEZIEGLER, D ;

OLIVENNES, F ;

TAIEB, J ;

DZIK, A ;

FRYDMAN, R .

HUMAN REPRODUCTION, 1994, 9 (09) :1607-1611

[8]

GaltierDereure F, 1996, HUM REPROD, V11, P1393

[9] Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome [J].

Hall, JE ;

Welt, CK ;

Cramer, DW .

HUMAN REPRODUCTION, 1999, 14 (02) :409-415

[10] Inhibin-B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening [J].

Hofmann, GE ;

Danforth, DR ;

Seifer, DB .

FERTILITY AND STERILITY, 1998, 69 (03) :474-477

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