Zinc-nucleic acid interaction

被引：222

作者：

Aoki, S

Kimura, E

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

[2] Hiroshima Univ, Fac Integrated Arts & Sci, Higashihiroshima 7398521, Japan

来源：

CHEMICAL REVIEWS | 2004年 / 104卷 / 02期

关键词：

D O I：

10.1021/cr020617u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of derivatives of Zn2+-cyclen complexes have been designed as prototypes of selective receptors of 'imide'- containing nucleobases, thymine (dT) and uracil (U), in aqueous solution at physiological pH. The Zn2+-cyclen complexes with polyaromatic pendants possess recognition efficiency in terms of Kd on the order of 10 μM in single- and double-stranded DNA (or RNA) to disrupt A-dT hydrogen bonds in double-stranded nucleic acids. A direct correlation was found between the binding of Tat to TAR RNA and up-regulation of HIV-1 mRNA transcription. The potent inhibition of HIV-1 TAR RNA-Tat peptide binding by Zn2+ complexes was described.

引用

页码：769 / 787

页数：19