Violation of distribution symmetry in statistical evaluation of absolute enantioselective synthesis

被引：33

作者：

Barabas, Bela

Caglioti, Luciano

Zucchi, Claudia

Maioli, Marco

Gal, Emese

Micskei, Karoly

Palyi, Gyula

机构：

[1] Univ Technol & Econ, Dept Stochast, H-1111 Budapest, Hungary

[2] Univ Roma La Sapienza, Dept Chem & Technol Biol Act Cpds, I-00185 Rome, Italy

[3] Univ Modena & Reggio Emilia, Dept Chem, I-41100 Modena, Italy

[4] Univ Modena & Reggio Emilia, Dept Math, I-4100 Modena, Italy

[5] Univ Debrecen, Inst Inorgan & Analyt Chem, H-4010 Debrecen, Hungary

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2007年 / 111卷 / 39期

关键词：

D O I：

10.1021/jp072945+

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Enantiomeric excesses obtained in absolute enantioselective synthesis by chiral autocatalysis (Soai-reaction) were statistically analyzed. Two sets of parallel experiments, which were performed under chemically different conditions, are available. One group contains 37, while the other contains 84 preparative results. The former group shows some interesting tendencies but does not give conclusive statistical results. The sample of 84 parallel experiments, providing 39 R- and 45 S-excesses have shown that these data represent two distinct, non-symmetric sets with different non-Gaussian distributions. Clear S preference was found.

引用

页码：11506 / 11510

页数：5

共 59 条

[1]

BALDI P, 1998, CALCOLO PROBABILITA, P138

[2]

BARTOSYNSKI R, 1996, PROBABILITY STAT INF, P729

[3] Mechanistic study of the Soai autocatalytic reaction informed by kinetic analysis [J].